Psychology professor Judith Grisel talks on Fresh Air about the neuroscience of addiction. She compares alcohol to a sledgehammer on the brain, cocaine is like a laser -it is very specific, whereas marijuana floods the brain with one specific effect. She explains how our brain learns to react against these addictive substances when they are used regularly to bring you to a state of balance, "homeostasis", which reduces the effects of drugs in the long run. Then she discusses binge drinking, the legalization of marijuana, among other things. Professor Grisel was a marijuana and alcohol addict in her youth, but she has been clean for 30 years. She is the author of the book "Never Enough: the Neuroscience and Experience of Addiction".
This NPR interview lasts 36':03", but it has a script, so it can be classified as C1.